Areas of Interest:
Major areas of investigation within laboratory: (1) Polypeptide growth factors, hormonal-like agents responsible for the regulation of growth and/or maintenance of viability of eukaryotic cells, and their receptors with respect to structure and mechanism. The action of nerve growth factor, epidermal growth factor, and basic fibroblast growth factor on responsive cultured cells (primarily PC12 and germane mutants) is being determined utilizing receptor chimaeras. (2) The co- and post-translational modification of the N-termini of nascent polypeptide. This is a key part of these processes and studies on the isolation, characterization, and cloning of several germane enzymes are in progress.
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